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UoS future medical scientists present impressive research work
By Mariecar Jara-Puyod November 09, 2017
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DUBAI: Education and reading plus imagination and motivation are equal to research, innovation and more research leading to better health.

Take it from at least 12 University of Sharjah medical and health sciences students who defended their team research works, completed between one and two years, before their esteemed administration officials and faculty members including fellow students on Wednesday morning.

Several had their turn in the afternoon with five other studies.

The research works, under the supervision of professors and with the aid of the university laboratory, are part of a 2014 agreement between the university and multi-national pharmaceutical/research-driven firm Boehringer Ingelheim (BI) that aims to nurture not only medical practitioners but more importantly erudite medical scientists in the fields of cardiovascular, diabetes, cancer, respiratory and neurological diseases.

Fifth year Pharmacy students Riham Ibrahim, Enas El Krewi, Ethar Fadl, Reem Al Zain, Amani Ahmed, and Asraa Mohammed wanted to know if there is a treatment for prostate cancer, a result of a study earlier done by one of their professors.

They came up with the “Synthesis of DNA Minor Groove Binders to Selectively Target the Androgen Response Element.”

Interviewed, Ibrahim who presented the study said: “On target is the treatment for prostate cancer by creating distamycin analog (a natural antibiotic that binds to the minor grooves of the DNA).”

Ahmed said: “We designed a new compound called T3 which is the anti-cancer and anti-bacteria. We synthesised this compound and we are already doing purifications before sending it for characterisations at the New York University in Abu Dhabi.”

Saying that clinical studies are part of medical research endeavours, Ahmed added: “We are hopeful that this compound (T3) will respond to prostate cancer.”

It was learnt that fourth year Medicine students Mae Khouly and Ronda Al Samhouri began in the “summer of 2017” a corollary research work to their “Effects of SAHA and 5-Aza-2 Deoxycytidine on GIP Receptors and Insulin Secretion in Human Pancreatic Cells: A Potential Novel Therapeutic Treatment for Diabetes Mellitus.”

SAHA is “a drug that makes the cell over express all proteins while GIP is a hormone released from an intestine filled with food.”

Explaining that in diabetics, the “GIP receptors are down regulated,” both said they wanted to know if once increased, these GIP receptors from a full intestine would result in the increase of insulin secretion. 

They added: “Yes, we found a way to increase the GIP receptors but there are side effects.”

Hence, the corollary study which will now focus on the GIP receptors coming from the bones.

With schizophrenia as one of its bases, fifth year Medicine students Alaa Hisham, Saja Al Taher, Nafisa Abbasher, and Namo Hamawndy worked on the study “Diabetes-Induced Depression: Brain-Derived Neurotrophic Factor (BDNF) as a Promising Therapeutic Target.”

BDNF are the growth factor proteins that act on certain neurons of the central nervous system and the peripheral nervous system.

They said diabetes and depression combined damage the brain.

From the study, the group will pursue further research until they get to the “perfect levels of the BDNF proteins that will regenerate the brain cells and be the curative treatment to diabetes and depression.”
 

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