President Donald Trump made his first major foray out of the White House since the coronavirus lockdown began in a push for economic reopening as the daily US death toll from the disease spiked.
It came as Britain became the country with the second most deaths in the world at 32,000, putting it above Italy in the grim ranking of national fatalities.
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Elsewhere in Europe, hard-hit Spain and France reported a levelling off of figures, offering hope that life could slowly start returning to normal, but in Latin America the death toll passed 15,000.
With experts warning of a severe global recession, many governments have been easing stay-at-home measures to try to revive reeling economies.
The US Capitol is seen in Washington, DC. File photo/AFP
"We can't keep our country closed for the next five years," Trump said on a trip to a mask-making factory in Arizona, conceding that some people would be "badly affected."
And in the latest sign his administration no longer considers the pandemic its top daily priority, the White House is set to disband the emergency task force handling the outbreak.
"I think we're starting to look at the Memorial Day (May 25) window, early June window" for shutting it down, Vice President Mike Pence said.
Trump urged US states to ease restrictions as he attempts to fire up the world's biggest economy before the November presidential election, when the high death toll and millions of lost jobs could cost him dearly.
At least 256,422 people have died of the novel coronavirus since the epidemic surfaced in China late last year, according to an AFP tally.
The United States is the worst-hit country, with more than 70,000 deaths, ahead of Britain where fatalities topped 32,000.
Workers close down a station for nightly cleaning due to the continued spread of the coronavirus in New York. AFP
The new UK toll from the Office for National Statistics and regional health bodies has not yet been incorporated into the government's deaths figure of 29,427.
The US registered 2,333 more deaths over the 24 hours to Tuesday evening, according to a Johns Hopkins University tracker, more than twice as many as the day before.
Some scientific models suggest the figure will rise to 3,000 a day by June.
In New York, the challenge was further highlighted when 15 children were hospitalized with a rare inflammatory disease possibly linked to the coronavirus, raising alarm in the medical community.
The children were diagnosed with Kawasaki disease, a mysterious illness that causes the walls of arteries to become inflamed, resulting in fever, skin peeling and joint pain.
Four of the patients tested positive for COVID-19 and six were found to have antibodies, suggesting they had previously been infected.
A woman arrives by ambulance to Wyckoff Hospital in New York. Bryan R. Smith/AFP
Countries across the world are balancing the need to revive stalled economies against the risk of a new wave of deadly infections.
In Germany, regional leaders pushed back against Chancellor Angela Merkel's pleas for caution, with the biggest state Bavaria saying it would reopen restaurants and hotels this month.
Hong Kong announced plans to reopen schools, cinemas, bars and beauty parlours from Friday, while Californian bookshops, florists and clothing stores will also be allowed to reopen at the end of the week.
Social distancing rules were eased in South Korea, where workers went back to offices on Wednesday, and museums and libraries were reopened.
And in ground-zero Wuhan, Chinese youngsters filed back to class on Wednesday for the first time since the city was shut down in January, wearing masks and walking past thermal scanners.
Agence France-Presse