Israel launched air strikes on Thursday on southern Gaza's Rafah after threatening to send troops into the city, where around 1.4 million Palestinians have sought shelter from around the territory.
Global powers trying to navigate a way to end the Israel-Hamas war have so far come up short, but a US envoy was expected in Israel on Thursday to try to secure a truce deal.
International concern has spiralled over the high civilian death toll and dire humanitarian crisis in the war sparked by Hamas's October 7 attack against Israel.
More than four months of relentless fighting and air strikes have flattened much of the Hamas-run coastal territory, pushing its population of around 2.4 million to the brink of famine, according to the UN.
International concern has in recent weeks centred on Gaza's southernmost city of Rafah, where more than 1.4 million people forced to flee their homes elsewhere in the territory are now living in crowded shelters and makeshift tents.
Palestinian children scramble for food as fears of a major famine loom large.
The last city untouched by Israeli ground troops, Rafah also serves as the main entry point via neighbouring Egypt for desperately needed relief supplies.
Israel has warned it will expand its ground operations into Rafah if Hamas does not free the remaining hostages held in Gaza by next month's start of the Muslim holy month Ramadan.
‘Waiting for death’
Combat and chaos have stalled sporadic aid deliveries for civilians in Gaza, while in Khan Yunis — a city just north of Rafah — medical charity Doctors Without Borders (MSF) said an Israeli tank had fired on a house sheltering their employees and families.
Two relatives of MSF staff were killed and six others injured, it said, condemning the strike in the "strongest possible terms".
When contacted by AFP about the incident, the Israeli army said its forces had "fired at a building that was identified as a building where terror activity is occurring", adding that it "regrets" harm to civilians.
In the same town, the Palestinian Red Crescent said another hospital was also hit by "artillery shelling".
Agence France-Presse