Rescuers inspect the site as a civil defence spokesman said the death toll from the Israeli strike on the Ajlah family home is 15 dead.

Gaza's civil defence agency said an Israeli air strike in the early hours of Saturday killed 15 people from a Palestinian family, including nine children and three women.

The strike hit the home of the Ajlah family in Al-Zawaida neighbourhood of central Gaza, civil defence spokesman Mahmud Bassal told the media. The Israeli military did not offer an immediate comment.

"The toll from the Israeli strike on the Ajlah family home and their warehouse in Al-Zawaida is 15 dead," Bassal said.

Bassal gave a list of those killed, including nine children and three women.

A witness said the strike took place shortly after midnight.

"Three rockets hit the house directly," Ahmed Abu al-Ghoul told the media as rescuers pulled bodies from the rubble of the flattened house.

"There were a lot of children and women inside... What have they done to deserve this?"

Palestinians inspect the site of an Israeli strike in Al Zawayda in the central Gaza Strip on Saturday. AFP

AFPTV footage of the aftermath, captured after dawn, showed rescuers searching for bodies under piles of collapsed concrete blocks.

More than 10 months of war between Israel and Hamas has left vast swathes of Gaza in ruins.

The war broke out after Hamas attacked Israel on October 7, which resulted in the deaths of 1,198 people, mostly civilians, according to the media tally based on official Israeli figures.

The Palestinian group Hamas also seized 251 people during the attack, 111 of whom are still held captive in Gaza, including 39 the Israeli military says are dead.

Israel's retaliatory military campaign has killed at least 40,005 people in Gaza, according to the health ministry of the Hamas-run territory.

Agence France-Presse